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» Home » Research Projects » National Grants II - 2008 » CAPMAT

» CAPMAT

Project title: CLINICAL, ANATOMOPATHOLOGICAL AND MOLECULAR CORRELATIONS FOR ESTABLISHING MATHEMATICAL MODELS EMPLOYED IN THE FUTURE EVOLUTION OF PROSTATE CANCER

Project number: PN II 42-105

Acronym: CAPMAT

Abstract: 

We propose to formulate mathematical models based on results of clinical, anatomopathological and molecular assays, reported to the future evolution and family predisposition to prostate cancer by IHC analysis of TGF, p53, EGFR, VEGF, AMACR, chromosomal abnormalities, BRCA1, BRCA2 by FISH , MLPA, LOH, MSI, and sequencing. The aim is to identify genetic risk factors in prostate cancer, proposing an integrative view on the pathogenesis and evolution of this malignancy. The biostatistics interpretation of results will be achieved by the application of specific mathematical models.

Partners:

1. University of Bucharest - DBBM (CO)

Project director: CS II VRABIE CAMELIA DOINA, PhD

2. “Sfantul Ioan” Clinical Emergency Hospital Bucharest

3. “Prof. Dr. Th. Burghele” Clinical Hospital Bucharest

4. FUNDENI CLINICAL INSTITUTE BUCHAREST

5.”Victor Babes” National Research and Development Institute in the Field of Pathology and Biomedical Sciences

6. Technical University of Constructions Bucharest

Rezultate:

- Etapa 1 - predata in februarie 2009
- Etapa 2 - predata in noiembrie 2009
- Etapa 3

Publicatii:

Articole ISI publicate (1):

- A. Ushenko, S. Yermolenko, P. Ivashko, K. Vladychenko, I. Gruia, C. Gavril─â, Spectropolarimetry of cancer change of biotissues, Journal of SPIE, subdomeniu New applications of correlation optics in biology and medicine, Vol. 7388, 30
Dec. 2009, ISSN: 0277-786X, (ISI).

Conferinte internationale (4):

- Gruia, S.B. Yermolenko, C. Gavrila, P.V. Ivashko, M. I. Gruia, T. ┼×tef─ânescu, Spectropolarimetry Features of Biotissue’s Malignant Changes, The XII  International Conference on Laser Applications in Life Sciences, June 9-11, 2010,  Oulu, Finland, http://www.ee.oulu.fi/LALS-2010/.

- I.Gruia, S.Yermolenko, M.I.Gruia, C.Gavrila, Spectral identification of tissue’s malignant changes, Proceedings of the 31st European Conference on Laser Interaction with Matter, September 6-10, 2010 Budapest, Hungary http://top-congress.hu/2010/eclim/index_1.htm 

- Camelia GAVRILA, Narcisa Teodorescu, Cristina Nartea, Management of prostate cancer based of Bayesian Networks, Proceedings Conference SymOrg 2010, 9-12 iunie 2010, Zlatibor, Serbia, ISBN: 978-86-7680-216-6, www.symorg.org .

- Geavlete P., Georgescu D., Jora T., Geavlete B. Prostate cancer in patients with PSA values between 2.5 – 4.0 ng/ml: predictive value of PSA velocity. SIU World Uro-Oncology update, 19 – 22 November 2008, Santiago, Chile, Urology 2008, vol.72(supl.5A):S84 (poster MP-4.02

Conferinte nationale (3):

- Angela PETRESCU, Narcisa TEODORESCU, Amelia PETRESCU, Maria WALLER , Camelia GAVRILA , Narcisa MANEA , Cezar PETRESCU, Statistical biological data in prostatic cancer, Proceedings of the ICRSMS 2010 Conferences, Arad 12 oct 2010, http://www.uav.ro/en/conferences/icrsms-2010 

- Camelia Doina Vrabie, Camellia Gavrila, Viorel Petrehus, Narcisa Teodorescu. (2009). The Monitoring Of The Prostate Cancer Based On Bayesian Networks. Sesiunea Anuala A Institutului National”Victor Babes” Si Al 6-Lea Simpozion National De Patologie, Bucharest, Nov, 3-5 (P53) Isbn: 978-973-708-443-9

Angela Petrescu, Maria Waller, CS Petrescu, Camelia Vrabie, Amelia Petrescu, Narcisa Manea, Nicoleta Ecaterina Branisteanu. Applied biostatistics on histopathology analysis in prostate cancer.[P 42] 2010. The annual session of the National Institute “Victor Babes”. The 7th national Symposium of Pathology “The personalized medicine”, Nov 9-12, 2010, Bucharest. ISBN: 978-973-708-521-4

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