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Titlu proiect: CORELATII CLINICE, ANATOMOPATOLOGICE SI MOLECULARE IN VEDEREA STABILIRII UNOR MODELE MATEMATICE UTILE IN PREDICTIA EVOLUTIEI CANCERULUI DE PROSTATA

Numar proiect: PN II 42-105

Acronim: CAPMAT

Rezumat:

Se propune stabilirea unor modele matematice bazate pe rezultatele evaluarii clinice, anatomopatologice si moleculare, raportate la predictia evolutiei si susceptibilitatea familiala in cancerul de prostata prin: analiza IHC a TGF, p53, EGFR, VEGF, AMACR; anomaliile cromozomiale, BRCA1, BRCA2 prin FISH, MLPA, LOH, MSI, si secventiere. Scopul este identificarea factorilor de risc genetici in cancerul de prostata, propunand o viziune integrativa asupra patogenezei si evolutiei acestei malignitati. Interpretarea biostatistica a rezultatelor obtinute se va realiza prin aplicarea de modele matematice specifice.

Parteneri:

1. Universitatea Bucuresti - DBBM (CO)

Director de proiect: CS II Dr. VRABIE CAMELIA DOINA

2.Spitalul Clinic de Urgenta Sfantul Ioan Bucuresti

3.Spitalul Clinic Prof. Dr. Th. Burghele Bucuresti

4.INSTITUTUL CLINIC FUNDENI BUCURESTI

5.Institutul National de Cercetare Dezvoltare in Domeniul Patologiei si Stiintelor Biomedicale Victor Babes

6.Universitatea Tehnica de Constructii Bucuresti

Rezultate:

- Etapa 1 - predata in februarie 2009
- Etapa 2 - predata in noiembrie 2009
- Etapa 3

Publicatii:

Articole ISI publicate (1):

- A. Ushenko, S. Yermolenko, P. Ivashko, K. Vladychenko, I. Gruia, C. Gavril─â, Spectropolarimetry of cancer change of biotissues, Journal of SPIE, subdomeniu New applications of correlation optics in biology and medicine, Vol. 7388, 30
Dec. 2009, ISSN: 0277-786X, (ISI).

Conferinte internationale (4):

- Gruia, S.B. Yermolenko, C. Gavrila, P.V. Ivashko, M. I. Gruia, T. ┼×tef─ânescu, Spectropolarimetry Features of Biotissue’s Malignant Changes, The XII  International Conference on Laser Applications in Life Sciences, June 9-11, 2010,  Oulu, Finland, http://www.ee.oulu.fi/LALS-2010/.

- I.Gruia, S.Yermolenko, M.I.Gruia, C.Gavrila, Spectral identification of tissue’s malignant changes, Proceedings of the 31st European Conference on Laser Interaction with Matter, September 6-10, 2010 Budapest, Hungary http://top-congress.hu/2010/eclim/index_1.htm 

- Camelia GAVRILA, Narcisa Teodorescu, Cristina Nartea, Management of prostate cancer based of Bayesian Networks, Proceedings Conference SymOrg 2010, 9-12 iunie 2010, Zlatibor, Serbia, ISBN: 978-86-7680-216-6, www.symorg.org .

- Geavlete P., Georgescu D., Jora T., Geavlete B. Prostate cancer in patients with PSA values between 2.5 – 4.0 ng/ml: predictive value of PSA velocity. SIU World Uro-Oncology update, 19 – 22 November 2008, Santiago, Chile, Urology 2008, vol.72(supl.5A):S84 (poster MP-4.02

Conferinte nationale (3):

- Angela PETRESCU, Narcisa TEODORESCU, Amelia PETRESCU, Maria WALLER , Camelia GAVRILA , Narcisa MANEA , Cezar PETRESCU, Statistical biological data in prostatic cancer, Proceedings of the ICRSMS 2010 Conferences, Arad 12 oct 2010, http://www.uav.ro/en/conferences/icrsms-2010 

- Camelia Doina Vrabie, Camellia Gavrila, Viorel Petrehus, Narcisa Teodorescu. (2009). The Monitoring Of The Prostate Cancer Based On Bayesian Networks. Sesiunea Anuala A Institutului National”Victor Babes” Si Al 6-Lea Simpozion National De Patologie, Bucharest, Nov, 3-5 (P53) Isbn: 978-973-708-443-9

Angela Petrescu, Maria Waller, CS Petrescu, Camelia Vrabie, Amelia Petrescu, Narcisa Manea, Nicoleta Ecaterina Branisteanu. Applied biostatistics on histopathology analysis in prostate cancer.[P 42] 2010. The annual session of the National Institute “Victor Babes”. The 7th national Symposium of Pathology “The personalized medicine”, Nov 9-12, 2010, Bucharest. ISBN: 978-973-708-521-4

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